Cargando…

Long‐term Exposure to the Anti‐inflammatory Agent Phenylbutazone Induces Kidney Tumors in Rats and Liver Tumors in Mice

Long‐term toxicity and carcinogenicity of phenylbutazone, a nonsteroidal anti‐inflammatory drug, were evaluated in F344/N rats and B6C3F1 mice. In 2‐year studies, phenylbutazone was given in corn oil by gavage 5 days per week to groups of 50 rats of each sex at doses of 0, 50, or 100 mg/kg body weig...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kari, Frank, Bucher, John, Haseman, Joseph, Eustis, Scot, Huff, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1995
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920813/ https://www.ncbi.nlm.nih.gov/pubmed/7744695 http://dx.doi.org/10.1111/j.1349-7006.1995.tb03048.x

Ejemplares similares

Toward of Safer Phenylbutazone Derivatives by Exploration of Toxicity Mechanism
por: Borges, Rosivaldo S., et al.
Publicado: (2019)

The Safety and Pharmacokinetics of Carprofen, Flunixin and Phenylbutazone in the Cape Vulture (Gyps coprotheres) following Oral Exposure
por: Fourie, Tamsyn, et al.
Publicado: (2015)

Effects of phenylbutazone, firocoxib, and dipyrone on the diuretic response to furosemide in horses
por: White, Julianne M., et al.
Publicado: (2023)

Chemicals associated with site-specific neoplasia in 1394 long-term carcinogenesis experiments in laboratory rodents.
por: Huff, J, et al.
Publicado: (1991)

Phenylbutazone (Bute, PBZ, EPZ): one drug across two species
por: Worboys, Michael, et al.
Publicado: (2018)

APTES-Modified SBA-15 as a Non-Toxic Carrier for Phenylbutazone
por: Dadej, Adrianna, et al.
Publicado: (2022)

Serum protein expression in Equine Glandular Gastric Disease (EGGD) induced by phenylbutazone
por: TESENA, Parichart, et al.
Publicado: (2019)

Enhancing the dissolution of phenylbutazone using Syloid® based mesoporous silicas for oral equine applications
por: Waters, Laura J., et al.
Publicado: (2018)

Long-term chemical carcinogenesis experiments for identifying potential human cancer hazards: collective database of the National Cancer Institute and National Toxicology Program (1976-1991).
por: Huff, J, et al.
Publicado: (1991)

Effects of phenylbutazone alone or in combination with a nutritional therapeutic on gastric ulcers, intestinal permeability, and fecal microbiota in horses
por: Whitfield‐Cargile, Canaan M., et al.
Publicado: (2021)

Phenylbutazone concentrations in synovial fluid following administration via intravenous regional limb perfusion in the forelimbs of six adult horses
por: O’Brien, Molly, et al.
Publicado: (2023)

Multiple-site carcinogenicity of benzene in Fischer 344 rats and B6C3F1 mice.
por: Huff, J E, et al.
Publicado: (1989)

Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy
por: Chen, Guiying, et al.
Publicado: (2016)

Liver Carcinogencsis by Methyl Carbamate in F344 Rats and Not in B6C3F1 Mice
por: Chan, Po C., et al.
Publicado: (1992)

Oxidative Alteration of Trp-214 and Lys-199 in Human Serum Albumin Increases Binding Affinity with Phenylbutazone: A Combined Experimental and Computational Investigation
por: Bertozo, Luiza de Carvalho, et al.
Publicado: (2018)

Absolute Configuration and Biological Evaluation of Novel Triterpenes as Possible Anti-Inflammatory or Anti-Tumor Agents
por: Wei, Zhenzhen, et al.
Publicado: (2022)

Melatonin: an anti-tumor agent for osteosarcoma
por: Fathizadeh, Hadis, et al.
Publicado: (2019)

Can Anti-Tumor Necrosis Factor Agents Be Discontinued in Patients with Inflammatory Bowel Disease?
por: Park, Jihye, et al.
Publicado: (2021)

Docking of THPDTPI: to explore P-selectin as a common target of anti-tumor, anti-thrombotic and anti-inflammatory agent
por: Zhu, Haimei, et al.
Publicado: (2017)

Green tea increases anti-inflammatory tristetraprolin and decreases pro-inflammatory tumor necrosis factor mRNA levels in rats
por: Cao, Heping, et al.
Publicado: (2007)

Effects of the Anti-Tumor Agents Trabectedin and Lurbinectedin on Immune Cells of the Tumor Microenvironment
por: Allavena, Paola, et al.
Publicado: (2022)

Regional Delivery of Anti-PD-1 Agent for Colorectal Liver Metastases Improves Therapeutic Index and Anti-Tumor Activity
por: Chai, Louis F., et al.
Publicado: (2021)

Effect of Pre- and Postoperative Phenylbutazone and Morphine Administration on the Breathing Response to Skin Incision, Recovery Quality, Behavior, and Cardiorespiratory Variables in Horses Undergoing Fetlock Arthroscopy: A Pilot Study
por: Conde Ruiz, Clara, et al.
Publicado: (2015)

Rare presentation of inflammatory myofibroblastic tumor in the kidney
por: Abduljawad, Hiba, et al.
Publicado: (2020)

Factors Associated with the Immunogenicity of Anti-Tumor Necrosis Factor Agents in Pediatric Patients with Inflammatory Bowel Disease
por: Kim, Ju Young, et al.
Publicado: (2021)

Melatonin: An Anti-Tumor Agent in Hormone-Dependent Cancers
por: Menéndez-Menéndez, Javier, et al.
Publicado: (2018)

Strengths and Challenges of Secretory Ribonucleases as AntiTumor Agents
por: Castro, Jessica, et al.
Publicado: (2021)

Comparative results of 327 chemical carcinogenicity studies.
por: Haseman, J K, et al.
Publicado: (1987)

Child inflammatory myofibroblastic tumor of the kidney misdiagnosed as Wilms' tumor: case report
por: Bai, Yu-Feng, et al.
Publicado: (2022)

Distinct anti-tumoral functions of adaptive immune cells in liver cancer
por: Schneider, Carlo, et al.
Publicado: (2012)

Antioxidant and anti-inflammatory agents in chronic liver diseases: Molecular mechanisms and therapy
por: Zhang, Chun-Ye, et al.
Publicado: (2023)

Chemically induced mouse liver tumors are resistant to treatment with atorvastatin
por: Braeuning, Albert, et al.
Publicado: (2014)

Characterization of the Inflammatory Microenvironment and Identification of Potential Therapeutic Targets in Wilms Tumors()()
por: Maturu, Paramahamsa, et al.
Publicado: (2014)

Inflammatory Pseudo-tumor of the Liver Accompanied by Eosinophilia
por: Matsumoto, Yoshihide, et al.
Publicado: (2021)

Liver Abscess Complicated with an Inflammatory Myofibroblastic Tumor
por: Rodrigues, Susana, et al.
Publicado: (2022)

Efficacy of iron supplementation in patients with inflammatory bowel disease treated with anti-tumor necrosis factor-alpha agents
por: Kim, Su Young, et al.
Publicado: (2020)

Furosemide, orlistat and non-steroidal anti-inflammatory agents—too much for the kidneys to handle!
por: Korzets, Asher, et al.
Publicado: (2009)

Carcinogenesis Studies of Dichlorvos in Fischer Rats and B6C3F1 Mice
por: Chan, Po C., et al.
Publicado: (1991)

Betulin Is a Potent Anti-Tumor Agent that Is Enhanced by Cholesterol
por: Mullauer, Franziska B., et al.
Publicado: (2009)

THE EFFECT OF LIVER REGENERATION ON TUMOR FORMATION IN RATS FED 4-DIMETHYLAMINOAZOBENZENE
por: Glinos, André D., et al.
Publicado: (1951)

Cannot write session to /tmp/vufind_sessions/sess_7vqe2o8u3rp1ee8c8d4l5shauk