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Direct Transplantation of Chronic Myelogenous Leukemia Cells into Nude Mice and Establishment of a Leukemic Stem Cell (Ph(1+), CD34(+)) Line Dependent on Mouse Bone Marrow Stromal Cells in vitro
Peripheral blood cells from a female patient with Ph(1)‐positive chronic myelogenous leukemia (CML) in blast crisis were serially transplanted in BALB/c nude mice for 16 passages. This in vivo cell line, designated CML‐N‐1, had Ph(1)chromosome abnormality and BCR gene rearrangement. The cells expres...
Autores principales: | Kubonishi, Ichiro, Takeuchi, Seisho, Uemura, Yoshiki, Kamioka, Mikio, Asahi, Yasutomo, Ohtsuki, Yuji, Miyoshi, Isao |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1995
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920846/ https://www.ncbi.nlm.nih.gov/pubmed/7540608 http://dx.doi.org/10.1111/j.1349-7006.1995.tb03078.x |
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