A New Water‐soluble Camptothecin Derivative, DX‐8951f, Exhibits Potent Antitumor Activity against Human Tumors in vitro and in vivo

CPT‐11, a semisynthetic derivative of camptothecin, exhibited strong antitumor activity against lymphoma, lung cancer, colorectal cancer, gastric cancer, ovarian cancer, and cervical cancer. CPT‐11 is a pro‐drug that is converted to an active metabolite, SN‐38, in vivo by enzymes such as carboxylest...

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Detalles Bibliográficos
Autores principales: Mitsui, Ikuo, Kumazawa, Eiji, Hirota, Yasuhide, Aonuma, Masashi, Sugimori, Masamichi, Ohsuki, Satoru, Uoto, Kouichi, Ejima, Akio, Terasawa, Hirofumi, Sato, Keiki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1995
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920901/
https://www.ncbi.nlm.nih.gov/pubmed/7559102
http://dx.doi.org/10.1111/j.1349-7006.1995.tb02468.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920901/
https://www.ncbi.nlm.nih.gov/pubmed/7559102
http://dx.doi.org/10.1111/j.1349-7006.1995.tb02468.x

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