Cargando…

Hepatocellular Carcinoma Induction in LEC Rats by a Low Dose of 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline

A food‐borne heterocyclic amine, 2‐amino‐3,8‐dimethylimidazo[4,5‐f]qninoxaline (MeIQx), induces hepatocellular carcinomas (HCCs) in F344 male rats at an incidence of 95%, when fed in the diet at 400 ppm for 61 weeks. In this study, the effect of a low dose of MeIQx was examined in Long‐Evans with ci...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sone, Hideko, Wakabayashi, Keiji, Kushida, Hiromi, Enomoto, Katsuhiko, Mori, Michio, Takeichi, Noritoshi, Tsuda, Hiroyuki, Sugimura, Takashi, Nagao, Minako
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1996
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920977/ https://www.ncbi.nlm.nih.gov/pubmed/8609044 http://dx.doi.org/10.1111/j.1349-7006.1996.tb00195.x

Ejemplares similares

Formation and Removal of DNA Adducts in the Liver of Rats Chronically Fed the Food‐borne Carcinogen, 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline
por: Hirose, Misako, et al.
Publicado: (1995)

Effects of Chronic Administration of Low Doses of 2‐Ammo‐3,8‐dimethylimidazo‐[4,5‐f]qumoxaline on Glutathione S‐Transferase Placental Form‐positive Foci Development in the Livers of Rats Fed a Choline‐deficient Diet
por: Sone, Hideko, et al.
Publicado: (1993)

DNA Adducts Formed by 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline in Rat Liver: Dose‐Response on Chronic Administration
por: Yamashita, Katsumi, et al.
Publicado: (1990)

Lack of Carcinogenicity of 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline (MeIQx) in Cynomolgus Monkeys
por: Ogawa, Kumiko, et al.
Publicado: (1999)

Lack of a Dose‐response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline or N‐Nitrosodiethylamine
por: Fukushima, Shoji, et al.
Publicado: (2002)

Inhibitory Effect of 2‐0‐Octadecylascorbic Acid in Agglutination Assay with Concanavalin A; Short‐term Examination of Rat Urinary Bladder Carcinogenesis
por: Suzuki, Mika, et al.
Publicado: (1991)

Mechanism of Oxidative DNA Damage Induced by a Heterocyclic Amine, 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline
por: Murata, Mariko, et al.
Publicado: (1999)

Effects of Chlorophyll a and b in Reducing Genotoxicity of 2-Amino-3,8-dimethylimidazo[4,5-F]quinoxaline (MeIQx)
por: Kocaoğlu Cenkci, Serap, et al.
Publicado: (2022)

Difference in Target Organs in Carcinogenesis with a Heterocyclic Amine, 2‐Amino‐3,4‐dimethylimidazo[4,5‐f]quinoline, in Different Strains of Mice
por: Fujita, Hirofumi, et al.
Publicado: (1999)

Inhibition of 2‐Amino‐3, 8‐dimethylimidazo[4,5‐f]quinoxaline‐mediated DNA‐adduct Formation by Chlorophyllin in Drosophila
por: Sugiyama, Chitose, et al.
Publicado: (1996)

Formation of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline‐ and 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline‐sulfamates by cDNA‐expressed Mammalian Phenol Sulfotransferases
por: Ozawa, Shogo, et al.
Publicado: (1995)

Metabolism of the food-borne carcinogens 2-amino-3-methylimidazo-[4,5-f]quinoline and 2-amino-3,8- dimethylimidazo[4,5-f]-quinoxaline in the rat as a model for human biomonitoring.
por: Turesky, R J, et al.
Publicado: (1993)

Down‐regulation of 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline (MeIQx)‐induced CYP1A2 Expression Is Associated with Bovine Lactoferrin Inhibition of MeIQx‐induced Liver and Colon Carcinogenesis in Rats
por: Fujita, Ken‐ichi, et al.
Publicado: (2002)

Enhancement by Cigarette Smoke Exposure of 2‐Amino‐3,8‐dimethylimidazo[4,5‐ f]quinoxaline‐induced Rat Hepatocarcinogenesis in Close Association with Elevation of Hepatic CYP1A2
por: Nishikawa, Akiyoshi, et al.
Publicado: (2002)

Two‐dimensional Electrophoretic Analysis of Hepatitis‐associated Polypeptides in Liver of LEC Rats Developing Spontaneous Hepatitis
por: Wirth, Peter J., et al.
Publicado: (1990)

DNA Modification by 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine in Rats
por: Takayama, Kyoko, et al.
Publicado: (1989)

Dose‐dependent Induction of 8‐Hydroxyguanine and Preneoplastic Foci in Rat Liver by a Food‐derived Carcinogen, 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline, at Low Dose Levels
por: Kato, Toshio, et al.
Publicado: (1996)

Abnormal Hepatic Iron Accumulation in LEC Rats
por: Kato, Junji, et al.
Publicado: (1993)

Lack of Hepatocarcinogenicity of Combinations of Low Doses of 2-amino-3, 8-dimethylimidazo[4,5- f ]quinoxaline and Diethylnitrosamine in Rats: Indication for the Existence of a Threshold for Genotoxic Carcinogens
por: Wei, Min, et al.
Publicado: (2012)

Detection of 2‐Amino‐1‐methyl‐6‐(4‐hydroxyphenyl)imidazo[4,5‐b]pyridine in Broiled Beef
por: Kurosaka, Reiko, et al.
Publicado: (1992)

Induction of Intestinal Adenocarcinomas by 2‐Amino‐l‐methyl‐6‐phenylimidazo‐[4,5‐b] pyridine in Nagase Analbuminemic Rats
por: Ochiai, Masako, et al.
Publicado: (1991)

Detection of Guanine‐C8‐2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine Adduct as a Single Spot on Thin‐layer Chromatography by Modification of the (32)P‐Postlabeling Method
por: Fukutome, Kazuo, et al.
Publicado: (1994)

Rare Activation of the Human c‐Ha‐ras Transgene of Mice in Hemangioendothelial Sarcomas and Liver Tumors Induced by Glu‐P‐1
por: Inoue, Rie, et al.
Publicado: (1996)

High Sensitivity of LEC Rats with Chronic Hepatitis to Hepatocarcinogenesis: Decreases in Unscheduled and Replicative DNA Synthesis of the Hepatocytes
por: Sakamoto, Hirofumi, et al.
Publicado: (1993)

Accumulation of Abnormally High Ploid Nuclei in the Liver of LEC Rats Developing Spontaneous Hepatitis
por: Fujimoto, Yoshinori, et al.
Publicado: (1989)

Differing Distribution of Hepatocyte Growth Factor‐positive Cells in the Liver of LEC Rats with Acute Hepatitis, Chronic Hepatitis and Hepatoma
por: Nakayama, Nobuaki, et al.
Publicado: (1995)

Abnormal Copper Accumulation in Non‐cancerous and Cancerous Liver Tissues of LEC Rats Developing Hereditary Hepatitis and Spontaneous Hepatoma
por: Li, Yu, et al.
Publicado: (1991)

Adduct Formation at C‐8 of Guanine on in vitro Reaction f the Ultimate Form of 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine with 2′‐Deoxyguanosine and Its Phosphate Esters
por: Nagaoka, Hiroaki, et al.
Publicado: (1992)

Induction of Intestinal Tumors and Lymphomas in C57BL/6N Mice by a Food‐borne Carcinogen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine
por: Ochiai, Masako, et al.
Publicado: (2002)

Efficient Method for Rapid Induction of Aberrant Crypt Foci in Rats with 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine
por: Ochiai, Masako, et al.
Publicado: (1996)

Caenorhabditis elegans Galectins LEC-6 and LEC-10 Interact with Similar Glycoconjugates in the Intestine
por: Maduzia, Lisa L., et al.
Publicado: (2011)

High Susceptibility to Hepatocellular Carcinoma Development in LEC Rats with Hereditary Hepatitis
por: Masuda, Ryuichi, et al.
Publicado: (1988)

Absence of p53 Mutations in Rat Colon Tumors Induced by 2‐Amino‐6‐methyldipyrido[1,2‐a:3′, 2′‐d]imidazole, 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline, or 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine
por: Makino, Hiroshi, et al.
Publicado: (1994)

Arabidopsis LEC1 and LEC2 Orthologous Genes Are Key Regulators of Somatic Embryogenesis in Cassava
por: Brand, Alejandro, et al.
Publicado: (2019)

Heteroglycoclusters With Dual Nanomolar Affinities for the Lectins LecA and LecB From Pseudomonas aeruginosa
por: Goyard, David, et al.
Publicado: (2019)

p53 Gene Mutation in Hepatocellular Carcinoma Induced by 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates
por: Fujimoto, Yoshinori, et al.
Publicado: (1994)

SPONTANEOUS OCCURRENCE OF PLACENTAL GLUTATHIONE S‐TRANSFERASE‐POSITIVE FOCI IN THE LIVERS OF LEC RATS
por: Oyamada, Masahito, et al.
Publicado: (1988)

Elevation of Serum Alpha‐fetoprotein and Proliferation of Oval Cells in the Livers of LEC Rats
por: Takahashi, Hidetoshi, et al.
Publicado: (1988)

Induced Expression of AtLEC1 and AtLEC2 Differentially Promotes Somatic Embryogenesis in Transgenic Tobacco Plants
por: Guo, Fengdan, et al.
Publicado: (2013)

Dose‐dependent Induction of Liver and Thyroid Neoplastic Lesions by Short‐term Administration of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline Combined with Partial Hepatectomy Followed by Phenobarbital or Low Dose 3′‐Methyl‐4‐dimethylaminoazobenzene Promotion
por: Tsuda, Hiroyuki, et al.
Publicado: (1988)

Cannot write session to /tmp/vufind_sessions/sess_ep8vnl6fll949s4lhnmckrd29h