A Topoisomerase II Inhibitor, NK109, Induces DNA Single‐ and Double‐strand Breaks and Apoptosis

2,3‐(Methylenedioxy)‐5‐methyl‐7‐hydroxy‐8‐methoxybenzo[c]phenanthridinium hydrogensulfate di‐hydrate, called NK109, is a benzo[c]phenanthridine derivative, which inhibits DNA topoisomerase II activity by stabilizing the DNA‐enzyme‐drug complex, and shows strong growth‐inhibitory effects on several h...

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Detalles Bibliográficos
Autores principales: Fukuda, Minoru, Inomata, Motoko, Nishio, Kazuto, Fukuoka, Kazuya, Kanzawa, Fumihiko, Arioka, Hitoshi, Ishida, Tomoyuki, Fukumoto, Hisao, Kurokawa, Hirokazu, Oka, Mikio, Saijo, Nagahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1996
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920997/
https://www.ncbi.nlm.nih.gov/pubmed/8957068
http://dx.doi.org/10.1111/j.1349-7006.1996.tb03114.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920997/
https://www.ncbi.nlm.nih.gov/pubmed/8957068
http://dx.doi.org/10.1111/j.1349-7006.1996.tb03114.x

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