Suppression of Human Pancreatic Cancer Growth in BALB/c Nude Mice by Manumycin, a Farnesyl:protein Transferase Inhibitor

Activating mutations of Ki‐ras have been detected in most human pancreatic adenocarcinomas. Since Ras protein requires farnesylation to function, we investigated the effects of manumycin, a potent farnesyl:protein transferase inhibitor, on the growth in nude mice of a human pancreatic cancer cell li...

Descripción completa

Detalles Bibliográficos
Autores principales: Ito, Toshio, Kawata, Sumio, Tamura, Shinji, Igura, Takumi, Nagase, Toshihiko, Miyagawa, Jun‐ichiro, Yamazaki, Eiji, Ishiguro, Hiroshi, Matsuzawa, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1996
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921057/
https://www.ncbi.nlm.nih.gov/pubmed/8609057
http://dx.doi.org/10.1111/j.1349-7006.1996.tb03146.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921057/
https://www.ncbi.nlm.nih.gov/pubmed/8609057
http://dx.doi.org/10.1111/j.1349-7006.1996.tb03146.x

Ejemplares similares