Cargando…

Suppression of Human Pancreatic Cancer Growth in BALB/c Nude Mice by Manumycin, a Farnesyl:protein Transferase Inhibitor

Activating mutations of Ki‐ras have been detected in most human pancreatic adenocarcinomas. Since Ras protein requires farnesylation to function, we investigated the effects of manumycin, a potent farnesyl:protein transferase inhibitor, on the growth in nude mice of a human pancreatic cancer cell li...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ito, Toshio, Kawata, Sumio, Tamura, Shinji, Igura, Takumi, Nagase, Toshihiko, Miyagawa, Jun‐ichiro, Yamazaki, Eiji, Ishiguro, Hiroshi, Matsuzawa, Yuji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1996
Materias:	Rapid Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921057/ https://www.ncbi.nlm.nih.gov/pubmed/8609057 http://dx.doi.org/10.1111/j.1349-7006.1996.tb03146.x

Ejemplares similares

Manumycin and gliotoxin derivative KT7595 block Ras farnesylation and cell growth but do not disturb lamin farnesylation and localization in human tumour cells.
por: Nagase, T., et al.
Publicado: (1997)

Effect of Pravastatin, a Potent 3‐Hydroxy‐3‐methylgliitaryl‐coenzyme A Reductase Inhibitor, on Survival of AH130 Hepatoma‐bearing Rats
por: Kawata, Sumio, et al.
Publicado: (1992)

Elevated Levels of Plasma Transforming Growth Factor‐β in Patients with Hepatocellular Carcinoma
por: Shirai, Yasuhiro, et al.
Publicado: (1992)

Modulation of c‐myc Expression by Transforming Growth Factor β1 in Human Hepatoma Cell Lines
por: Ito, Nobuyuki, et al.
Publicado: (1990)

Use of Farnesyl Transferase Inhibitors in an Ageing Model in Drosophila
por: Brandt, Annely, et al.
Publicado: (2023)

Manumycin induces apoptosis in prostate cancer cells
por: Li, Jing-Gao, et al.
Publicado: (2014)

Expression of Transforming Growth Factor‐β1 mRNA in Human Hepatocellular Carcinoma
por: Ito, Nobuyuki, et al.
Publicado: (1990)

Molecular docking and simulation of Curcumin with Geranylgeranyl Transferase1 (GGTase1) and Farnesyl Transferase (FTase)
por: Subramani, Parasuraman Aiya, et al.
Publicado: (2015)

Induction of Adenocarcinomas in the Glandular Stomach of BALB/c Mice Treated with N‐Methyl‐N‐nitrosourea
por: Tatematsu, Masae, et al.
Publicado: (1992)

Potential of Farnesyl Transferase Inhibitors in Combination Regimens in Squamous Cell Carcinomas
por: Kessler, Linda, et al.
Publicado: (2021)

Analyzing the postulated inhibitory effect of Manumycin A on farnesyltransferase
por: Hagemann, Anna, et al.
Publicado: (2022)

Contrasting Actions of Estradiol on the Growth of Human Gastric Cancer Xenografts in Nude Mice
por: Tokunaga, Akira, et al.
Publicado: (1989)

107 Immunomodulatory Effects of Manumycin-type Antibiotics on Human Macrophages
por: Striz, Ilja, et al.
Publicado: (2012)

HETEROTRANSPLANTATION OF ARGYROPHIL SMALL CELL CARCINOMA OF THE UTERINE CERVIX INTEGRATING HPV16 DNA INTO NUDE MICE
por: Ichimura, Hiroshi, et al.
Publicado: (1988)

Modulation of the mevalonate pathway and cell growth by pravastatin and d-limonene in a human hepatoma cell line (Hep G2).
por: Kawata, S., et al.
Publicado: (1994)

SPONTANEOUS OCCURRENCE OF PLACENTAL GLUTATHIONE S‐TRANSFERASE‐POSITIVE FOCI IN THE LIVERS OF LEC RATS
por: Oyamada, Masahito, et al.
Publicado: (1988)

Farnesyl transferase inhibitors induce extended remissions in transgenic mice with mature B cell lymphomas
por: Field, Kenneth A, et al.
Publicado: (2008)

Manumycin Polyketides Act as Molecular Glues Between UBR7 and P53
por: Isobe, Yosuke, et al.
Publicado: (2020)

Gene Expression of Placental Glutathione S‐Transferase in Hereditary Hepatitis and Spontaneous Hepatocarcinogenesis of LEC Strain Rats
por: Masuda, Ryuichi, et al.
Publicado: (1989)

Positive Foci of Glutathione S‐Transferase Placental Form in the Liver of Rats Given Furfural by Oral Administration
por: Shimizu, Akio, et al.
Publicado: (1989)

Chemotherapy induces breast cancer stem cell enrichment through repression of glutathione S-transferase Mu
por: He, Jing, et al.
Publicado: (2023)

Experimental infection of Balb/c nude mice with Hepatitis E virus
por: Huang, Fen, et al.
Publicado: (2009)

Reference genomes for BALB/c Nude and NOD/SCID mouse models
por: Schmid-Siegert, Emanuel, et al.
Publicado: (2023)

Phase I and pharmacokinetic study of irinotecan in combination with R115777, a farnesyl protein transferase inhibitor
por: Sparreboom, A, et al.
Publicado: (2004)

Breast Cancer Stem Cells Survive Periods of Farnesyl-Transferase Inhibitor-Induced Dormancy by Undergoing Autophagy
por: Chaterjee, Moumita, et al.
Publicado: (2011)

LEVELS OF GLUTATHIONES TRANSFERASE π mRNA IN HUMAN LUNG CANCER CELL LINES CORRELATE WITH THE RESISTANCE TO CISPLATIN AND CARBOPLATIN
por: Nakagawa, Kazuhiko, et al.
Publicado: (1988)

Synergistic effect of farnesyl transferase inhibitor lonafarnib combined with chemotherapeutic agents against the growth of hepatocellular carcinoma cells
por: Wang, Jialiang, et al.
Publicado: (2017)

Inhibition of the Heat Shock Protein A (HSPA) Family Potentiates the Anticancer Effects of Manumycin A
por: Sojka, Damian Robert, et al.
Publicado: (2021)

Transformation by Hras(G12V) is Consistently Associated with Mutant Allele Copy Gains and is Reversed by Farnesyl Transferase Inhibition
por: Chen, Xu, et al.
Publicado: (2013)

Weekly paclitaxel, gemcitabine, and external irradiation followed by randomized farnesyl transferase inhibitor R115777 for locally advanced pancreatic cancer
por: Rich, Tyvin A, et al.
Publicado: (2012)

Gut Microbiota Shifts in Pup Athymic BALB/c Mice: An Updated Identification in Nude Mice
por: Li, Yuting, et al.
Publicado: (2019)

Deconvolution of diffuse gastric cancer and the suppression of CD34 on the BALB/c nude mice model
por: Yoon, Seon-Jin, et al.
Publicado: (2020)

Effects of Para-Toluenesulfonamide on Canine Melanoma Xenotransplants in a BALB/c Nude Mouse Model
por: Lin, Chien-Teng, et al.
Publicado: (2022)

Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumourcells
por: Paolo, A Di, et al.
Publicado: (2000)

Manumycin A corrects aberrant splicing of Clcn1 in myotonic dystrophy type 1 (DM1) mice
por: Oana, Kosuke, et al.
Publicado: (2013)

Immunohistochemical Type Distinction of a‐Fetoprotein in Various a‐Fetoprotein‐secreting Tumors
por: Okamoto, Tsukasa, et al.
Publicado: (1993)

Enhanced Antiproliferative and Apoptotic Response of HT-29 Adenocarcinoma Cells to Combination of Photoactivated Hypericin and Farnesyltransferase Inhibitor Manumycin A
por: Sačková, Veronika, et al.
Publicado: (2011)

Manumycin A inhibits triple-negative breast cancer growth through LC3-mediated cytoplasmic vacuolation death
por: Singha, P K, et al.
Publicado: (2013)

Activation of a Cryptic Manumycin-Type Biosynthetic Gene Cluster of Saccharothrix espanaensis DSM44229 by Series of Genetic Manipulations
por: Gorniaková, Dominika, et al.
Publicado: (2021)

An Essential Farnesylated Kinesin in Trypanosoma brucei
por: Engelson, Erin J., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_2gkjqh4ie7bk8a5gqbnt6bdhed