Biological Activity and Intracellular Metabolism of ZD1694 in Human Leukemia Cell Lines with Different Resistance Mechanisms to Antifolate Drugs

The biological activity and cellular metabolism of ZD1694, a novel folate‐based thymidylate synthase (TS) inhibitor, were analyzed in a human leukemia cell line, MOLT‐3, and its antifolate‐resistant sublines with different mechanisms of resistance to methotrexate (MTX), trimetrexate (TMQ) and N(10)‐...

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Detalles Bibliográficos
Autores principales: Takemura, Yuzuru, Kobayashi, Hiroyuki, Miyachi, Hayato, Gibson, William, Kimbell, Rosemary, Jackman, Ann L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1996
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921156/
https://www.ncbi.nlm.nih.gov/pubmed/8698629
http://dx.doi.org/10.1111/j.1349-7006.1996.tb00291.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921156/
https://www.ncbi.nlm.nih.gov/pubmed/8698629
http://dx.doi.org/10.1111/j.1349-7006.1996.tb00291.x

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