Chemoprevention by Pravastatin, a 3‐Hydroxy‐3‐methylglutaryl‐coenzyme A Reductase Inhibitor, of N‐Methyl‐N‐nitrosourea‐induced Colon Carcinogenesis in F344 Rats

A potential chemopreventive action of pravastatin (Pr), a 3‐hydroxy‐3‐methylglutaryl‐coenzyme A redutase inhibitor, on colon carcinogenesis was evaluated in F344 rats. All rats at 7 weeks of age received an intrarectal dose of 2 mg of N‐methyl‐N‐nitrosourea 3 times weekly for 2 weeks in experiment I...

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Detalles Bibliográficos
Autores principales: Narisawa, Tomio, Morotomi, Masami, Fukaura, Yoko, Hasebe, Makiko, Ito, Michiko, Aizawa, Rika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1996
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921171/
https://www.ncbi.nlm.nih.gov/pubmed/8797885
http://dx.doi.org/10.1111/j.1349-7006.1996.tb02103.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921171/
https://www.ncbi.nlm.nih.gov/pubmed/8797885
http://dx.doi.org/10.1111/j.1349-7006.1996.tb02103.x

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