In vitro Enhancement of Antitumor Activity of a Water‐soluble Duocarmycin Derivative, KW‐2189, by Caffeine‐mediated DNA‐repair Inhibition in Human Lung Cancer Cells

Duocarmycins, including KW‐2189, bind in the minor groove of double‐stranded DNA at A‐T‐rich sequences, followed by covalent bonding with N‐3 of adenine in preferred sequences. We examined the effect of DNA‐repair modulators, such as caffeine and aphidicolin, on the cytotoxicity of duocarmycins towa...

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Detalles Bibliográficos
Autores principales: Ogasawara, Hayato, Nishio, Kazuto, Ishida, Tomoyuki, Arioka, Hitoshi, Fukuoka, Kazuya, Saijo, Nagahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1997
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921316/
https://www.ncbi.nlm.nih.gov/pubmed/9439677
http://dx.doi.org/10.1111/j.1349-7006.1997.tb00326.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921316/
https://www.ncbi.nlm.nih.gov/pubmed/9439677
http://dx.doi.org/10.1111/j.1349-7006.1997.tb00326.x

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