Effect of Glutathione Depletion on Cisplatin Resistance in Cancer Cells Transfected with the γ‐Glutamylcysteine Synthetase Gene

Overexpression of the human γ‐glutamylcysteine synthetase (γ‐GCS) gene resulted in cisplatin resistance with an increased glutathione (GSH) content, increased ATP‐dependent glutatbione S‐conjugate export pump (GS‐X pump) activity and decreased platinum accumulation in human lung cancer cells transfe...

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Detalles Bibliográficos
Autores principales: Kurokawa, Hirokazu, Nishio, Kazuto, Ishida, Tomoyuki, Arioka, Hitoshi, Fukuoka, Kazuya, Nomoto, Taisuke, Fukumoto, Hisao, Yokote, Hideyuki, Saijo, Nagahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921367/
https://www.ncbi.nlm.nih.gov/pubmed/9119737
http://dx.doi.org/10.1111/j.1349-7006.1997.tb00354.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921367/
https://www.ncbi.nlm.nih.gov/pubmed/9119737
http://dx.doi.org/10.1111/j.1349-7006.1997.tb00354.x

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