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Effect of CPT‐11 on Lipid Peroxide Level in Mouse Tissues
We examined the effects of CPT‐11 on lipid peroxide level and glutathione peroxidase (GSHpx) activity as indices of the toxicity of this antitumor agent in mouse and rat tissues. After CPT‐11 (100 mg/kg, i.p.) administration, the lipid peroxide level in the heart increased 1.5 fold (mice) and 1.3 fo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
1997
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921459/ https://www.ncbi.nlm.nih.gov/pubmed/9247609 http://dx.doi.org/10.1111/j.1349-7006.1997.tb00411.x |
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author | Sadzuka, Yasuyuki Hirota, Sadao |
author_facet | Sadzuka, Yasuyuki Hirota, Sadao |
author_sort | Sadzuka, Yasuyuki |
collection | PubMed |
description | We examined the effects of CPT‐11 on lipid peroxide level and glutathione peroxidase (GSHpx) activity as indices of the toxicity of this antitumor agent in mouse and rat tissues. After CPT‐11 (100 mg/kg, i.p.) administration, the lipid peroxide level in the heart increased 1.5 fold (mice) and 1.3 fold (rats) over the control levels. GSHpx activity decreased to 64% of the control. In the lung, the lipid peroxide level and GSHpx activity increased 2.5 fold and decreased to 74% after CPT‐11 administration, respectively, compared with the control values. These results suggested that CPT‐11 may cause cardiotoxicity and pulmotoxicity. In rat hone marrow, the lipid peroxide level increased on the 2nd day after CPT‐11 injection. We suggest that in both single and combination treatment with CPT‐11, the possibility of side effects should be taken into consideration. |
format | Online Article Text |
id | pubmed-5921459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1997 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59214592018-05-11 Effect of CPT‐11 on Lipid Peroxide Level in Mouse Tissues Sadzuka, Yasuyuki Hirota, Sadao Jpn J Cancer Res Article We examined the effects of CPT‐11 on lipid peroxide level and glutathione peroxidase (GSHpx) activity as indices of the toxicity of this antitumor agent in mouse and rat tissues. After CPT‐11 (100 mg/kg, i.p.) administration, the lipid peroxide level in the heart increased 1.5 fold (mice) and 1.3 fold (rats) over the control levels. GSHpx activity decreased to 64% of the control. In the lung, the lipid peroxide level and GSHpx activity increased 2.5 fold and decreased to 74% after CPT‐11 administration, respectively, compared with the control values. These results suggested that CPT‐11 may cause cardiotoxicity and pulmotoxicity. In rat hone marrow, the lipid peroxide level increased on the 2nd day after CPT‐11 injection. We suggest that in both single and combination treatment with CPT‐11, the possibility of side effects should be taken into consideration. Blackwell Publishing Ltd 1997-05 /pmc/articles/PMC5921459/ /pubmed/9247609 http://dx.doi.org/10.1111/j.1349-7006.1997.tb00411.x Text en |
spellingShingle | Article Sadzuka, Yasuyuki Hirota, Sadao Effect of CPT‐11 on Lipid Peroxide Level in Mouse Tissues |
title | Effect of CPT‐11 on Lipid Peroxide Level in Mouse Tissues |
title_full | Effect of CPT‐11 on Lipid Peroxide Level in Mouse Tissues |
title_fullStr | Effect of CPT‐11 on Lipid Peroxide Level in Mouse Tissues |
title_full_unstemmed | Effect of CPT‐11 on Lipid Peroxide Level in Mouse Tissues |
title_short | Effect of CPT‐11 on Lipid Peroxide Level in Mouse Tissues |
title_sort | effect of cpt‐11 on lipid peroxide level in mouse tissues |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921459/ https://www.ncbi.nlm.nih.gov/pubmed/9247609 http://dx.doi.org/10.1111/j.1349-7006.1997.tb00411.x |
work_keys_str_mv | AT sadzukayasuyuki effectofcpt11onlipidperoxidelevelinmousetissues AT hirotasadao effectofcpt11onlipidperoxidelevelinmousetissues |