Cytotoxicity of Trimetrexate against Antifolate‐resistant Human T‐Cell Leukemia Cell Lines Developed in Oxidized or Reduced Folate

Cytotoxicity of trimetrexate (TMQ), a lipophilic dihydrofolate reductase inhibitor, was examined in antifolate‐resistant human T‐cell leukemia cell lines developed in oxidized or reduced folate. An approximately 60‐fold methotrexate (MTX)‐resistant subline was developed in oxidized folate (pter‐oylg...

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Detalles Bibliográficos
Autores principales: Miyachi, Hayato, Takemura, Yuzuru, Kobayashi, Hiroyuki, Ando, Yasuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921512/
https://www.ncbi.nlm.nih.gov/pubmed/9369939
http://dx.doi.org/10.1111/j.1349-7006.1997.tb00467.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921512/
https://www.ncbi.nlm.nih.gov/pubmed/9369939
http://dx.doi.org/10.1111/j.1349-7006.1997.tb00467.x

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