Computer simulations of the signalling network in FLT3 (+)-acute myeloid leukaemia – indications for an optimal dosage of inhibitors against FLT3 and CDK6

BACKGROUND: Mutations in the FMS-like tyrosine kinase 3 (FLT3) are associated with uncontrolled cellular functions that contribute to the development of acute myeloid leukaemia (AML). We performed computer simulations of the FLT3-dependent signalling network in order to study the pathways that are i...

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Detalles Bibliográficos
Autores principales: Buetti-Dinh, Antoine, Friedman, Ran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921566/
https://www.ncbi.nlm.nih.gov/pubmed/29699481
http://dx.doi.org/10.1186/s12859-018-2145-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921566/
https://www.ncbi.nlm.nih.gov/pubmed/29699481
http://dx.doi.org/10.1186/s12859-018-2145-y

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