A VCP inhibitor substrate trapping approach (VISTA) enables proteomic profiling of endogenous ERAD substrates

Endoplasmic reticulum (ER)–associated degradation (ERAD) mediates the proteasomal clearance of proteins from the early secretory pathway. In this process, ubiquitinated substrates are extracted from membrane-embedded dislocation complexes by the AAA ATPase VCP and targeted to the cytosolic 26S prote...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Edmond Y., To, Milton, Tran, Erica, Ador Dionisio, Lorraine T., Cho, Hyejin J., Baney, Katherine L. M., Pataki, Camille I., Olzmann, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2018
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921570/
https://www.ncbi.nlm.nih.gov/pubmed/29514927
http://dx.doi.org/10.1091/mbc.E17-08-0514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921570/
https://www.ncbi.nlm.nih.gov/pubmed/29514927
http://dx.doi.org/10.1091/mbc.E17-08-0514

Ejemplares similares