Characterization of a Human Small‐cell Lung Cancer Cell Line Resistant to a New Water‐soluble Camptothecin Derivative, DX‐8951f

DX‐8951f, a water‐soluble and non‐pro‐drug analogue of camptothecin, exhibits a strong inhibitory action on DNA topoisomerase I (Topo I) and in vitro cytotoxicity against various human cancer cell lines. In order to elucidate the mechanisms of its cytotoxicity, we established a DX‐8951f‐resistant ce...

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Detalles Bibliográficos
Autores principales: Nomoto, Taisuke, Nishio, Kazuto, Ishida, Tomoyuki, Mori, Masatomo, Saijo, Nagahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921713/
https://www.ncbi.nlm.nih.gov/pubmed/9914787
http://dx.doi.org/10.1111/j.1349-7006.1998.tb00513.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921713/
https://www.ncbi.nlm.nih.gov/pubmed/9914787
http://dx.doi.org/10.1111/j.1349-7006.1998.tb00513.x

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