Suppression of Anti‐microtubule Agent‐induced Apoptosis by Nitric Oxide: Possible Mechanism of a New Drug Resistance

The propensity of a cell to undergo apoptosis has been proposed to be a determinant of sensitivity to anti‐microtubule agents. The anti‐microtubule agents vincristine and paclitaxel induce key features of apoptosis, such as intranucleosomal DNA fragmentation and changes in nuclear morphology in the...

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Autores principales: Ogura, Tsutomu, DeGeorge, George, Tatemichi, Masayuki, Esumi, Hiroyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921764/
https://www.ncbi.nlm.nih.gov/pubmed/9548448
http://dx.doi.org/10.1111/j.1349-7006.1998.tb00549.x
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author Ogura, Tsutomu
DeGeorge, George
Tatemichi, Masayuki
Esumi, Hiroyasu
author_facet Ogura, Tsutomu
DeGeorge, George
Tatemichi, Masayuki
Esumi, Hiroyasu
author_sort Ogura, Tsutomu
collection PubMed
description The propensity of a cell to undergo apoptosis has been proposed to be a determinant of sensitivity to anti‐microtubule agents. The anti‐microtubule agents vincristine and paclitaxel induce key features of apoptosis, such as intranucleosomal DNA fragmentation and changes in nuclear morphology in the human neuroblastoma cell line, NB‐39‐nu. Nitric oxide (NO) generated from NO‐releasing drugs prevented anti‐microtubule agent‐induced apoptosis in this cell line. The mechanism of suppression of apoptosis by NO appears to be via the inhibition of an interleukin‐1β converting enzyme‐like protease cascade. This finding reveals a new biological function of NO, as well as a new molecular insight into resistance to chemotherapy with anti‐microtubule agents.
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spelling pubmed-59217642018-05-11 Suppression of Anti‐microtubule Agent‐induced Apoptosis by Nitric Oxide: Possible Mechanism of a New Drug Resistance Ogura, Tsutomu DeGeorge, George Tatemichi, Masayuki Esumi, Hiroyasu Jpn J Cancer Res Article The propensity of a cell to undergo apoptosis has been proposed to be a determinant of sensitivity to anti‐microtubule agents. The anti‐microtubule agents vincristine and paclitaxel induce key features of apoptosis, such as intranucleosomal DNA fragmentation and changes in nuclear morphology in the human neuroblastoma cell line, NB‐39‐nu. Nitric oxide (NO) generated from NO‐releasing drugs prevented anti‐microtubule agent‐induced apoptosis in this cell line. The mechanism of suppression of apoptosis by NO appears to be via the inhibition of an interleukin‐1β converting enzyme‐like protease cascade. This finding reveals a new biological function of NO, as well as a new molecular insight into resistance to chemotherapy with anti‐microtubule agents. Blackwell Publishing Ltd 1998-02 /pmc/articles/PMC5921764/ /pubmed/9548448 http://dx.doi.org/10.1111/j.1349-7006.1998.tb00549.x Text en
spellingShingle Article
Ogura, Tsutomu
DeGeorge, George
Tatemichi, Masayuki
Esumi, Hiroyasu
Suppression of Anti‐microtubule Agent‐induced Apoptosis by Nitric Oxide: Possible Mechanism of a New Drug Resistance
title Suppression of Anti‐microtubule Agent‐induced Apoptosis by Nitric Oxide: Possible Mechanism of a New Drug Resistance
title_full Suppression of Anti‐microtubule Agent‐induced Apoptosis by Nitric Oxide: Possible Mechanism of a New Drug Resistance
title_fullStr Suppression of Anti‐microtubule Agent‐induced Apoptosis by Nitric Oxide: Possible Mechanism of a New Drug Resistance
title_full_unstemmed Suppression of Anti‐microtubule Agent‐induced Apoptosis by Nitric Oxide: Possible Mechanism of a New Drug Resistance
title_short Suppression of Anti‐microtubule Agent‐induced Apoptosis by Nitric Oxide: Possible Mechanism of a New Drug Resistance
title_sort suppression of anti‐microtubule agent‐induced apoptosis by nitric oxide: possible mechanism of a new drug resistance
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921764/
https://www.ncbi.nlm.nih.gov/pubmed/9548448
http://dx.doi.org/10.1111/j.1349-7006.1998.tb00549.x
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