Somatic Mutations of the PTEN/MMAC1 Gene in Fifteen Japanese Endometrial Cancers: Evidence for Inactivation of Both Alleles

Loss of heterozygosity (LOH) of chromosome 10q is observed in approximately 40% of endometrial cancers. Mutations in PTEN/MMAC1, a gene recently isolated from the 10q23 region, are responsible for two dominantly inherited neoplastic syndromes, Cowden disease and Bannayan‐Zonana syndrome. Somatic mut...

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Detalles Bibliográficos
Autores principales: Kurose, Keisuke, Bando, Koichi, Fukino, Koichi, Sugisaki, Yuichi, Araki, Tsutomu, Emi, Mitsuru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921910/
https://www.ncbi.nlm.nih.gov/pubmed/9765621
http://dx.doi.org/10.1111/j.1349-7006.1998.tb00638.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5921910/
https://www.ncbi.nlm.nih.gov/pubmed/9765621
http://dx.doi.org/10.1111/j.1349-7006.1998.tb00638.x

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