Acquired resistance to temsirolimus is associated with integrin α7 driven chemotactic activity of renal cell carcinoma in vitro

The mechanistic target of the rapamycin (mTOR) inhibitor, temsirolimus, has significantly improved the outcome of patients with renal cell carcinoma (RCC). However, development of temsirolimus-resistance limits its effect and metastatic progression subsequently recurs. Since integrin α7 (ITGA7) is s...

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Detalles Bibliográficos
Autores principales: Engl, Tobias, Rutz, Jochen, Maxeiner, Sebastian, Fanguen, Sorel, Juengel, Eva, Koschade, Sebastian, Roos, Frederik, Khoder, Wael, Tsaur, Igor, Blaheta, Roman A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922352/
https://www.ncbi.nlm.nih.gov/pubmed/29721158
http://dx.doi.org/10.18632/oncotarget.24650

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922352/
https://www.ncbi.nlm.nih.gov/pubmed/29721158
http://dx.doi.org/10.18632/oncotarget.24650

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