Cargando…
Precision cancer therapy: profiting from tumor specific defects in the DNA damage tolerance system
DNA damage tolerance (DDT) enables replication to continue in the presence of a damaged template and constitutes a key step in DNA interstrand crosslink repair. In this way DDT minimizes replication stress inflicted by a wide range of endogenous and exogenous agents, and provides a critical first li...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922359/ https://www.ncbi.nlm.nih.gov/pubmed/29721165 http://dx.doi.org/10.18632/oncotarget.24777 |