Nonalcoholic steatohepatitis severity is defined by a failure in compensatory antioxidant capacity in the setting of mitochondrial dysfunction

AIM: To comprehensively evaluate mitochondrial (dys) function in preclinical models of nonalcoholic steatohepatitis (NASH). METHODS: We utilized two readily available mouse models of nonalcoholic fatty liver disease (NAFLD) with or without progressive fibrosis: Lep(ob)/Lep(ob) (ob/ob) and FATZO mice...

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Detalles Bibliográficos
Autores principales: Boland, Michelle L, Oldham, Stephanie, Boland, Brandon B, Will, Sarah, Lapointe, Jean-Martin, Guionaud, Silvia, Rhodes, Christopher J, Trevaskis, James L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2018
Materias:
Basic Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922994/
https://www.ncbi.nlm.nih.gov/pubmed/29713129
http://dx.doi.org/10.3748/wjg.v24.i16.1748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5922994/
https://www.ncbi.nlm.nih.gov/pubmed/29713129
http://dx.doi.org/10.3748/wjg.v24.i16.1748

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