Gene Expression of Pneumocystis murina after Treatment with Anidulafungin Results in Strong Signals for Sexual Reproduction, Cell Wall Integrity, and Cell Cycle Arrest, Indicating a Requirement for Ascus Formation for Proliferation

The echinocandins are a class of antifungal agents that target β-1,3-d-glucan (BG) biosynthesis. In the ascigerous Pneumocystis species, treatment with these drugs depletes the ascus life cycle stage, which contains BG, but large numbers of forms which do not express BG remain in the infected lungs....

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Detalles Bibliográficos
Autores principales: Cushion, Melanie T., Ashbaugh, Alan, Hendrix, Keeley, Linke, Michael J., Tisdale, Nikeya, Sayson, Steven G., Porollo, Aleksey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923105/
https://www.ncbi.nlm.nih.gov/pubmed/29463544
http://dx.doi.org/10.1128/AAC.02513-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923105/
https://www.ncbi.nlm.nih.gov/pubmed/29463544
http://dx.doi.org/10.1128/AAC.02513-17

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