TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth

Acetylation of microtubules (MT) confers mechanical stability necessary for numerous functions including cell cycle and intracellular transport. Although αTAT1 is a major MT acetyltransferase, how this enzyme is regulated remains much less clear. Here we report TGF-β-activated kinase 1 (TAK1) as a k...

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Detalles Bibliográficos
Autores principales: Shah, Nirav, Kumar, Sanjay, Zaman, Naveed, Pan, Christopher C., Bloodworth, Jeffrey C., Lei, Wei, Streicher, John M., Hempel, Nadine, Mythreye, Karthikeyan, Lee, Nam Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923212/
https://www.ncbi.nlm.nih.gov/pubmed/29703898
http://dx.doi.org/10.1038/s41467-018-04121-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923212/
https://www.ncbi.nlm.nih.gov/pubmed/29703898
http://dx.doi.org/10.1038/s41467-018-04121-y

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