The cysteine-reactive small molecule ebselen facilitates effective SOD1 maturation

Superoxide dismutase-1 (SOD1) mutants, including those with unaltered enzymatic activity, are known to cause amyotrophic lateral sclerosis (ALS). Several destabilizing factors contribute to pathogenicity including a reduced ability to complete the normal maturation process which comprises folding, m...

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Detalles Bibliográficos
Autores principales: Capper, Michael J., Wright, Gareth S. A., Barbieri, Letizia, Luchinat, Enrico, Mercatelli, Eleonora, McAlary, Luke, Yerbury, Justin J., O’Neill, Paul M., Antonyuk, Svetlana V., Banci, Lucia, Hasnain, S. Samar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923229/
https://www.ncbi.nlm.nih.gov/pubmed/29703933
http://dx.doi.org/10.1038/s41467-018-04114-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923229/
https://www.ncbi.nlm.nih.gov/pubmed/29703933
http://dx.doi.org/10.1038/s41467-018-04114-x

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