Bayesian nonparametric discovery of isoforms and individual specific quantification

Most human protein-coding genes can be transcribed into multiple distinct mRNA isoforms. These alternative splicing patterns encourage molecular diversity, and dysregulation of isoform expression plays an important role in disease etiology. However, isoforms are difficult to characterize from short-...

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Detalles Bibliográficos
Autores principales: Aguiar, Derek, Cheng, Li-Fang, Dumitrascu, Bianca, Mordelet, Fantine, Pai, Athma A., Engelhardt, Barbara E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923247/
https://www.ncbi.nlm.nih.gov/pubmed/29703885
http://dx.doi.org/10.1038/s41467-018-03402-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923247/
https://www.ncbi.nlm.nih.gov/pubmed/29703885
http://dx.doi.org/10.1038/s41467-018-03402-w

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