Clickable prodrugs bearing potent and hydrolytically cleavable nicotinamide phosphoribosyltransferase inhibitors

PURPOSE: Our previous study indicated that carborane containing small-molecule 1-(hydroxymethyl)-7-(4′-(trans-3″-(3′″-pyridyl)acrylamido)butyl)-1,7-dicarbadodecaborane (hm-MC4-PPEA), was a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt). Nampt has been shown to be upregulated in m...

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Detalles Bibliográficos
Autores principales: Sadrerafi, Keivan, Mason, Emilia O, Lee, Mark W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923274/
https://www.ncbi.nlm.nih.gov/pubmed/29731606
http://dx.doi.org/10.2147/DDDT.S152685

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923274/
https://www.ncbi.nlm.nih.gov/pubmed/29731606
http://dx.doi.org/10.2147/DDDT.S152685

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