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Application of droplet digital PCR in the analysis of genome integration and organization of the transgene in BAC transgenic mice
Transgenic (Tg) mice containing bacterial artificial chromosome (BAC) DNA are widely used for gene expression analysis and gene therapy models because BAC transgenes provide gene expression at physiological levels with the same developmental timing as endogenous genes. To ensure correct interpretati...
Autores principales: | Nakagaki, Ayumi, Urakawa, Asuka, Hirano, Shiori, Anami, Takeru, Kishino, Tatsuya |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923295/ https://www.ncbi.nlm.nih.gov/pubmed/29703985 http://dx.doi.org/10.1038/s41598-018-25001-x |
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