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MR-Guided Delivery of AAV2-BDNF into the Entorhinal Cortex of Non-Human Primates

Brain-derived neurotrophic factor (BDNF) gene delivery to the entorhinal cortex is a candidate for treatment of Alzheimer’s disease (AD) to reduce neurodegeneration that is associated with memory loss. Accurate targeting of the entorhinal cortex in AD is complex due to the deep and atrophic state of...

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Detalles Bibliográficos
Autores principales: Nagahara, Alan H., Wilson, Bayard R., Ivasyk, Iryna, Kovacs, Imre, Rawalji, Saytam, Bringas, John R., Pivirotto, Phillip J., Sebastian, Waldy San, Samaranch, Lluis, Bankiewicz, Krystof S., Tuszynski, Mark H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924461/
https://www.ncbi.nlm.nih.gov/pubmed/29535375
http://dx.doi.org/10.1038/s41434-018-0010-2