Resistance to 6-Methylpurine is Conferred by Defective Adenine Phosphoribosyltransferase in Tetrahymena

6-methylpurine (6mp) is a toxic analog of adenine that inhibits RNA and protein synthesis and interferes with adenine salvage mediated by adenine phosphoribosyltransferase (APRTase). Mutants of the ciliated protist Tetrahymena thermophila that are resistant to 6mp were isolated in 1974, but the mech...

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Detalles Bibliográficos
Autores principales: Akematsu, Takahiko, Findlay, Andrew, Fukuda, Yasuhiro, E. Pearlman, Ronald, Loidl, Josef, Orias, Eduardo, P. Hamilton, Eileen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924521/
https://www.ncbi.nlm.nih.gov/pubmed/29570682
http://dx.doi.org/10.3390/genes9040179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924521/
https://www.ncbi.nlm.nih.gov/pubmed/29570682
http://dx.doi.org/10.3390/genes9040179

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