The Human Tyrosyl-DNA Phosphodiesterase 1 (hTdp1) Inhibitor NSC120686 as an Exploratory Tool to Investigate Plant Tdp1 Genes

The hTdp1 (human tyrosyl-DNA phosphodiesterase 1) inhibitor NSC120686 has been used, along with topoisomerase inhibitors, as a pharmacophoric model to restrain the Tdp1 activity as part of a synergistic treatment for cancer. While this compound has an end-point application in medical research, in pl...

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Detalles Bibliográficos
Autores principales: Macovei, Anca, Pagano, Andrea, Sabatini, Maria Elisa, Grandi, Sofia, Balestrazzi, Alma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924528/
https://www.ncbi.nlm.nih.gov/pubmed/29597329
http://dx.doi.org/10.3390/genes9040186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924528/
https://www.ncbi.nlm.nih.gov/pubmed/29597329
http://dx.doi.org/10.3390/genes9040186

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