Pancreatic β cells overexpressing hIAPP impaired mitophagy and unbalanced mitochondrial dynamics

Human islet amyloid polypeptide (hIAPP), or amylin, has the tendency to aggregate into insoluble amyloid fibrils, a typical feature of islets from type 2 diabetes individuals. Thus, we investigated comparatively the impact of hIAPP on key pathways involved in pancreatic beta survival. INS1E-hIAPP ce...

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Detalles Bibliográficos
Autores principales: Hernández, Miriam García, Aguilar, Ana García, Burillo, Jesús, Oca, Raquel Gómez, Manca, Maria Antonietta, Novials, Ana, Alcarraz-Vizan, Gema, Guillén, Carlos, Benito, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924657/
https://www.ncbi.nlm.nih.gov/pubmed/29705815
http://dx.doi.org/10.1038/s41419-018-0533-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924657/
https://www.ncbi.nlm.nih.gov/pubmed/29705815
http://dx.doi.org/10.1038/s41419-018-0533-x

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