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Pancreatic β cells overexpressing hIAPP impaired mitophagy and unbalanced mitochondrial dynamics

Human islet amyloid polypeptide (hIAPP), or amylin, has the tendency to aggregate into insoluble amyloid fibrils, a typical feature of islets from type 2 diabetes individuals. Thus, we investigated comparatively the impact of hIAPP on key pathways involved in pancreatic beta survival. INS1E-hIAPP ce...

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Detalles Bibliográficos
Autores principales:	Hernández, Miriam García, Aguilar, Ana García, Burillo, Jesús, Oca, Raquel Gómez, Manca, Maria Antonietta, Novials, Ana, Alcarraz-Vizan, Gema, Guillén, Carlos, Benito, Manuel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924657/ https://www.ncbi.nlm.nih.gov/pubmed/29705815 http://dx.doi.org/10.1038/s41419-018-0533-x

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