Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy

Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging. Stem cells exhibit attenuated DNA damage response (DDR) and are hypersensitive to IR, as compared to differentiated non-stem cells. We performed...

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Detalles Bibliográficos
Autores principales: Fabbrizi, Maria Rita, Meyer, Barbara, Misri, Sandeep, Raj, Suyash, Zobel, Cheri L., Hallahan, Dennis E., Sharma, Girdhar G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924762/
https://www.ncbi.nlm.nih.gov/pubmed/29706648
http://dx.doi.org/10.1038/s41419-018-0559-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924762/
https://www.ncbi.nlm.nih.gov/pubmed/29706648
http://dx.doi.org/10.1038/s41419-018-0559-0

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