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Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy
Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging. Stem cells exhibit attenuated DNA damage response (DDR) and are hypersensitive to IR, as compared to differentiated non-stem cells. We performed...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924762/ https://www.ncbi.nlm.nih.gov/pubmed/29706648 http://dx.doi.org/10.1038/s41419-018-0559-0 |