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Conformational sampling of membranes by Akt controls its activation and inactivation
The protein kinase Akt controls myriad signaling processes in cells, ranging from growth and proliferation to differentiation and metabolism. Akt is activated by a combination of binding to the lipid second messenger PI(3,4,5)P(3) and its subsequent phosphorylation by phosphoinositide-dependent kina...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924885/ https://www.ncbi.nlm.nih.gov/pubmed/29632185 http://dx.doi.org/10.1073/pnas.1716109115 |