Spider toxin inhibits gating pore currents underlying periodic paralysis

Gating pore currents through the voltage-sensing domains (VSDs) of the skeletal muscle voltage-gated sodium channel Na(V)1.4 underlie hypokalemic periodic paralysis (HypoPP) type 2. Gating modifier toxins target ion channels by modifying the function of the VSDs. We tested the hypothesis that these...

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Detalles Bibliográficos
Autores principales: Männikkö, Roope, Shenkarev, Zakhar O., Thor, Michael G., Berkut, Antonina A., Myshkin, Mikhail Yu, Paramonov, Alexander S., Kulbatskii, Dmitrii S., Kuzmin, Dmitry A., Sampedro Castañeda, Marisol, King, Louise, Wilson, Emma R., Lyukmanova, Ekaterina N., Kirpichnikov, Mikhail P., Schorge, Stephanie, Bosmans, Frank, Hanna, Michael G., Kullmann, Dimitri M., Vassilevski, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924911/
https://www.ncbi.nlm.nih.gov/pubmed/29636418
http://dx.doi.org/10.1073/pnas.1720185115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924911/
https://www.ncbi.nlm.nih.gov/pubmed/29636418
http://dx.doi.org/10.1073/pnas.1720185115

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