Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma

In order to clarify regions of production and to discriminate processing methods, quantitative and qualitative analyses for saccharides and terpenes in 35 batches of Alismatis Rhizoma were performed. Methodologies included HPLC—PDA, HPLC—VWD and UHPLC—MS(n), combined with principal component analysi...

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Autores principales: Gao, Xiaoxv, Sun, Chengpeng, Yu, Zhenglong, Cang, Jian, Tian, Xiangge, Huo, Xiaokui, Feng, Lei, Liu, Xinguang, Wang, Chao, Zhang, Baojing, Ma, Xiaochi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925412/
https://www.ncbi.nlm.nih.gov/pubmed/29719785
http://dx.doi.org/10.1016/j.apsb.2017.09.004
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author Gao, Xiaoxv
Sun, Chengpeng
Yu, Zhenglong
Cang, Jian
Tian, Xiangge
Huo, Xiaokui
Feng, Lei
Liu, Xinguang
Wang, Chao
Zhang, Baojing
Ma, Xiaochi
author_facet Gao, Xiaoxv
Sun, Chengpeng
Yu, Zhenglong
Cang, Jian
Tian, Xiangge
Huo, Xiaokui
Feng, Lei
Liu, Xinguang
Wang, Chao
Zhang, Baojing
Ma, Xiaochi
author_sort Gao, Xiaoxv
collection PubMed
description In order to clarify regions of production and to discriminate processing methods, quantitative and qualitative analyses for saccharides and terpenes in 35 batches of Alismatis Rhizoma were performed. Methodologies included HPLC—PDA, HPLC—VWD and UHPLC—MS(n), combined with principal component analysis (PCA) and partial least squares regression techniques (PLSR). The inhibitory effects of triterpenes and Alismatis Rhizoma extracts on lipase activity were evaluated in vitro. PLSR analysis revealed significant positive correlations (R(2) = 0.5795) between the contents of triterpenes 10, 14, 15, 18 and 22 and the inhibitory effects of Alismatis Rhizoma. The present study establishes an effective method for simultaneous determination of multiple components, and identifies key bioactive triterpenes. These results can be used for systematic and novel analytical strategies for the quality control of Alismatis Rhizoma production.
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spelling pubmed-59254122018-05-01 Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma Gao, Xiaoxv Sun, Chengpeng Yu, Zhenglong Cang, Jian Tian, Xiangge Huo, Xiaokui Feng, Lei Liu, Xinguang Wang, Chao Zhang, Baojing Ma, Xiaochi Acta Pharm Sin B Original Article In order to clarify regions of production and to discriminate processing methods, quantitative and qualitative analyses for saccharides and terpenes in 35 batches of Alismatis Rhizoma were performed. Methodologies included HPLC—PDA, HPLC—VWD and UHPLC—MS(n), combined with principal component analysis (PCA) and partial least squares regression techniques (PLSR). The inhibitory effects of triterpenes and Alismatis Rhizoma extracts on lipase activity were evaluated in vitro. PLSR analysis revealed significant positive correlations (R(2) = 0.5795) between the contents of triterpenes 10, 14, 15, 18 and 22 and the inhibitory effects of Alismatis Rhizoma. The present study establishes an effective method for simultaneous determination of multiple components, and identifies key bioactive triterpenes. These results can be used for systematic and novel analytical strategies for the quality control of Alismatis Rhizoma production. Elsevier 2018-03 2017-09-30 /pmc/articles/PMC5925412/ /pubmed/29719785 http://dx.doi.org/10.1016/j.apsb.2017.09.004 Text en © 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Gao, Xiaoxv
Sun, Chengpeng
Yu, Zhenglong
Cang, Jian
Tian, Xiangge
Huo, Xiaokui
Feng, Lei
Liu, Xinguang
Wang, Chao
Zhang, Baojing
Ma, Xiaochi
Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma
title Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma
title_full Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma
title_fullStr Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma
title_full_unstemmed Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma
title_short Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma
title_sort correlation analysis between the chemical contents and bioactivity for the quality control of alismatis rhizoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925412/
https://www.ncbi.nlm.nih.gov/pubmed/29719785
http://dx.doi.org/10.1016/j.apsb.2017.09.004
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