RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems

Reactivation of p53 and induction of tumor cell apoptosis (RITA) is a small molecule that blocks p53–MDM2 interaction, thereby reactivating p53 in tumors. RITA can induce exclusive apoptosis in cancer cells independently of the p53 pathway; however, the resistance of cancer cells remains a major dra...

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Detalles Bibliográficos
Autores principales: Shin, Daiha, Kim, Eun Hye, Lee, Jaewang, Roh, Jong-Lyel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925444/
https://www.ncbi.nlm.nih.gov/pubmed/28582730
http://dx.doi.org/10.1016/j.redox.2017.05.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925444/
https://www.ncbi.nlm.nih.gov/pubmed/28582730
http://dx.doi.org/10.1016/j.redox.2017.05.025

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