Half-life–extended recombinant coagulation factor IX–albumin fusion protein is recycled via the FcRn-mediated pathway

The neonatal Fc receptor (FcRn) has a pivotal role in albumin and IgG homeostasis. Internalized IgG captured by FcRn under acidic endosomal conditions is recycled to the cell surface where exocytosis and a shift to neutral pH promote extracellular IgG release. Although a similar mechanism is propose...

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Detalles Bibliográficos
Autores principales: Chia, Jenny, Louber, Jade, Glauser, Isabelle, Taylor, Shirley, Bass, Greg T., Dower, Steve K., Gleeson, Paul A., Verhagen, Anne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925791/
https://www.ncbi.nlm.nih.gov/pubmed/29523681
http://dx.doi.org/10.1074/jbc.M117.817064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925791/
https://www.ncbi.nlm.nih.gov/pubmed/29523681
http://dx.doi.org/10.1074/jbc.M117.817064

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