G1–checkpoint Function Including a Cyclin‐dependent Kinase 2 Regulatory Pathway as Potential Determinant of 7–Hydroxystaurosporine (UCN‐01)‐induced Apoptosis and G1–phase Accumulation

7–Hydroxystaurosporine (UCN‐01), which was originally identified as a protein kinase C selective inhibitor, is currently in clinical trials as an anti‐cancer drug. We previously showed that UCN‐01 induced preferential G1–phase accumulation in tumor cells and this effect was associated with the retin...

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Detalles Bibliográficos
Autores principales: Akiyama, Tadakazu, Sugiyama, Kazuyo, Shimizu, Makiko, Tamaoki, Tatsuya, Akinaga, Shiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1999
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926038/
https://www.ncbi.nlm.nih.gov/pubmed/10665655
http://dx.doi.org/10.1111/j.1349-7006.1999.tb00721.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926038/
https://www.ncbi.nlm.nih.gov/pubmed/10665655
http://dx.doi.org/10.1111/j.1349-7006.1999.tb00721.x

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