Effective Irinotecan (CPT‐11)‐containing Liposomes: Intraliposomal Conversion to the Active Metabolite SN‐38

Irinotecan hydrochloride (CPT‐11) is a prodrug of SN‐38, which is an active metabolite with anti‐tumor activity and side toxicity. The activities of CPT‐11 and SN‐38 depend on the closed lactone ring form of SN‐38. We have examined the tissue distributions of the closed and open forms of CPT‐11 and...

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Detalles Bibliográficos
Autores principales: Sadzuka, Yasuyuki, Hirotsu, Sachiyo, Hirota, Sadao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1999
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926044/
https://www.ncbi.nlm.nih.gov/pubmed/10189894
http://dx.doi.org/10.1111/j.1349-7006.1999.tb00737.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926044/
https://www.ncbi.nlm.nih.gov/pubmed/10189894
http://dx.doi.org/10.1111/j.1349-7006.1999.tb00737.x

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