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Effective Irinotecan (CPT‐11)‐containing Liposomes: Intraliposomal Conversion to the Active Metabolite SN‐38
Irinotecan hydrochloride (CPT‐11) is a prodrug of SN‐38, which is an active metabolite with anti‐tumor activity and side toxicity. The activities of CPT‐11 and SN‐38 depend on the closed lactone ring form of SN‐38. We have examined the tissue distributions of the closed and open forms of CPT‐11 and...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
1999
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926044/ https://www.ncbi.nlm.nih.gov/pubmed/10189894 http://dx.doi.org/10.1111/j.1349-7006.1999.tb00737.x |