A Dual Topoisomerase Inhibitor, TAS‐103, Induces Apoptosis in Human Cancer Cells

TAS‐103 (6‐[[2‐(dimethylamino)ethyl]amino]‐3‐hydroxy‐7H‐indeno[2,1‐c]quinolin‐7‐one dihydrochloride), a dual topoisomerase (topo) inhibitor, was developed as an anticancer agent by targeting topo I and topo II and has previously been shown to be effective against lung tumors. In this study, we inves...

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Detalles Bibliográficos
Autores principales: Ohyama, Tomoko, Li, Yin, Utsugi, Teruhiro, Irie, Shinji, Yamada, Yuji, Sato, Taka‐aki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1999
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926110/
https://www.ncbi.nlm.nih.gov/pubmed/10429663
http://dx.doi.org/10.1111/j.1349-7006.1999.tb00802.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926110/
https://www.ncbi.nlm.nih.gov/pubmed/10429663
http://dx.doi.org/10.1111/j.1349-7006.1999.tb00802.x

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