Uptake and Intracellular Distribution of Amrubicin, a Novel 9‐Amino‐anthracycline, and Its Active Metabolite Amrubicinol in P388 Murine Leukemia Cells

Amrubicin, a 9‐aminoanthracycline anti‐cancer drug, and its C‐13 hydroxyl metabolite amrubicinol, were examined for growth‐inhibitory activity as well as cellular uptake and distribution in P388 murine leukemia cells and doxorubicin‐resistant P388 cells. Also discussed are the differences in the mec...

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Detalles Bibliográficos
Autores principales: Yamaoka, Takashi, Hanada, Mitsuharu, Ichii, Shinji, Morisada, Shinya, Noguchi, Toshihiro, Yanagi, Yoshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1999
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926123/
https://www.ncbi.nlm.nih.gov/pubmed/10429662
http://dx.doi.org/10.1111/j.1349-7006.1999.tb00801.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926123/
https://www.ncbi.nlm.nih.gov/pubmed/10429662
http://dx.doi.org/10.1111/j.1349-7006.1999.tb00801.x

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