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Hypomethylation of CpG Sites and c‐myc Gene Overexpression in Hepatocellular Carcinomas, but Not Hyperplastic Nodules, Induced by a Choline‐deficient L‐Amino Acid‐defined Diet in Rats

We have investigated aberrant methylation of CpG nucleotides (CpG sites) and gene expression of c‐myc during hepatocarcinogenesis induced by a choline‐deficient, L‐amino acid‐defined (CDAA) diet in rats. Male Fischer 344 rats, 6 weeks old, were continuously given a CDAA diet for 50 and 75 weeks and...

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Detalles Bibliográficos
Autores principales:	Tsujiuchi, Toshifumi, Tsutsumi, Masahiro, Sasaki, Yasutaka, Takahama, Makoto, Konishi, Yoichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1999
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926157/ https://www.ncbi.nlm.nih.gov/pubmed/10551317 http://dx.doi.org/10.1111/j.1349-7006.1999.tb00834.x

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