Differential effect of amyloid beta peptides on mitochondrial axonal trafficking depends on their state of aggregation and binding to the plasma membrane

Inhibition of mitochondrial axonal trafficking by amyloid beta (Aβ) peptides has been implicated in early pathophysiology of Alzheimer’s Disease (AD). Yet, it remains unclear whether the loss of motility inevitably induces the loss of mitochondrial function, and whether restoration of axonal traffic...

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Detalles Bibliográficos
Autores principales: Zhang, Liang, Trushin, Sergey, Christensen, Trace A., Tripathi, Utkarsh, Hong, Courtney, Geroux, Rachel E., Howell, Kyle G., Poduslo, Joseph F., Trushina, Eugenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926207/
https://www.ncbi.nlm.nih.gov/pubmed/29477640
http://dx.doi.org/10.1016/j.nbd.2018.02.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926207/
https://www.ncbi.nlm.nih.gov/pubmed/29477640
http://dx.doi.org/10.1016/j.nbd.2018.02.003

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