HeLa Cell Transformants Overproducing Mouse Metallothionein Show in vivo Resistance to cis‐Platinum in Nude Mice

Plasmid pSV2MT‐I encoding mouse metallothionein‐I (MT‐I) designed to be expressed under the control of an SV40 promoter was introduced into human HeLa S3 cells. Several transformants (HeLa/MTH) carrying multi‐copies of mouse MT‐I cDNA in their genomes were isolated. These transformants produced 4 to...

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Detalles Bibliográficos
Autores principales: Toyoda, Haruka, Mizushima, Tomoe, Satoh, Masahiko, Iizuka, Narushi, Nomoto, Akio, Chiba, Harumi, Mita, Masaharu, Naganuma, Akira, Himeno, Seiichiro, Imura, Nobumasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2000
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926218/
https://www.ncbi.nlm.nih.gov/pubmed/10744049
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00864.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926218/
https://www.ncbi.nlm.nih.gov/pubmed/10744049
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00864.x

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