Regulation of Dihydropyrimidine Dehydrogenase and Pyrimidine Nucleoside Phosphorylase Activities by Growth Factors and Subsequent Effects on 5‐Fluorouracil Sensitivity in Tumor Cells

Dihydropyrimidine dehydrogenase (DPD) and pyrimidine nucleoside phosphorylase (PyNPase) are the first and rate‐limiting enzymes that regulate 5‐fluorouracil (5‐FU) metabolism, and tumoral DPD activity appears to be a promising predictor of 5‐FU sensitivity. However, the regulatory mechanisms determi...

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Detalles Bibliográficos
Autores principales: Ueda, Masatsugu, Kitaura, Kozo, Kusada, Osamu, Mochizuki, Yoshino, Yamada, Naomi, Terai, Yoshito, Kumagai, Koji, Ueki, Ken, Ueki, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2000
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926278/
https://www.ncbi.nlm.nih.gov/pubmed/11092985
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00903.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926278/
https://www.ncbi.nlm.nih.gov/pubmed/11092985
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00903.x

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