Improved in vivo Antitumor Efficacy and Reduced Systemic Toxicity of Carboxymethylpullulan‐peptide‐doxorubicin Conjugates

The antitumor efficacy of the conjugate of doxorubicin (DXR) and carboxymethylpullulan (CMPul) with Phe‐Gly spacer (CMPul‐FG‐DXR) was evaluated using murine tumor models and compared with that of DXR. The conjugate exhibited higher antitumor efficacy against Lewis lung carcinoma than DXR. Complete t...

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Detalles Bibliográficos
Autores principales: Nogusa, Hideo, Hamana, Hiroshi, Uchida, Naomi, Maekawa, Ryuji, Yoshioka, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2000
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926308/
https://www.ncbi.nlm.nih.gov/pubmed/11123434
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00922.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926308/
https://www.ncbi.nlm.nih.gov/pubmed/11123434
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00922.x

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