The Novel Anticancer Drug KRN5500 Interacts with, but is Hardly Transported by, Human P‐Glycoprotein

The interaction of the novel anticancer drug KRN5500, a spicamycin derivative, with human Pglycoprotein (P‐gp) was analyzed from the viewpoint of cellular pharmacokinetics, i.e. by means of [(3)H]azidopine photoaffinity labeling, cellular accumulation and transcellular transport experiments. In this...

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Detalles Bibliográficos
Autores principales: Takara, Kohji, Tanigawara, Yusuke, Komada, Fusao, Nishiguchi, Kohshi, Sakaeda, Toshiyuki, Okumura, Katsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2000
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926333/
https://www.ncbi.nlm.nih.gov/pubmed/10761713
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00938.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926333/
https://www.ncbi.nlm.nih.gov/pubmed/10761713
http://dx.doi.org/10.1111/j.1349-7006.2000.tb00938.x

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